As a "dedicated nutrient source" for probiotics, prebiotics in Beijianyichang prebiotics and probiotics products promote their growth and activity through multiple mechanisms. This process can be broken down into three core dimensions: nutrient supply, metabolic synergy, and ecological optimization.
From a basic nutritional perspective, ingredients like fructooligosaccharides and galacto-oligosaccharides added to Beijianyichang prebiotics and probiotics are typical non-digestible carbohydrates. These substances cannot be directly absorbed by the human body due to a lack of enzymes to decompose them, but they can reach the intestine intact and serve as an "energy meal" for probiotics. For example, Bifidobacterium spp. possess specific transport proteins on their cell membranes that efficiently recognize and absorb fructooligosaccharides, breaking them down into monosaccharides via β-fructosidase for ATP synthesis. This precise nutritional combination gives probiotics preferential growth in the intestine, increasing their growth rate by 2-3 times compared to prebiotics without supplementation.
This metabolic synergy further amplifies the growth-promoting effects of prebiotics. When probiotics break down prebiotics, they produce short-chain fatty acids such as acetate, propionate, and butyrate. These metabolites not only provide a secondary energy source for the probiotics themselves but also lower the intestinal pH, creating an acidic environment that is unfavorable for pathogens. Experiments have shown that when the concentration of short-chain fatty acids reaches 20-40 mmol/L, the adhesion of harmful bacteria such as Salmonella and Escherichia coli decreases by over 60%, while the colonization stability of Bifidobacteria increases by 40%. This "bacteria-supporting-bacteria" cycle extends the survival of probiotics in the intestine to over 72 hours.
In terms of optimizing the intestinal microbiome, prebiotics reshape the microbial structure by selectively stimulating specific bacterial communities. The isomaltooligosaccharides in beijianyichang prebiotics and probiotics specifically promote the growth of Lactobacilli. The α-1,6 glycosidic bonds in their molecular structure are efficiently hydrolyzed by Lactobacilli's glucoamylase, while most harmful bacteria lack the corresponding enzymes to utilize this component. This differentiated nutritional supply increased the proportion of probiotics in the intestinal microbiota from 15% before supplementation to over 35%, forming a dominant bacterial community dominated by Bifidobacteria and Lactobacilli, effectively inhibiting the excessive proliferation of opportunistic pathogens.
The probiotic-stimulating effect of prebiotics on probiotic growth is also reflected in the strengthening of the microbial interaction network. When prebiotics stimulate the proliferation of Bifidobacteria, the exopolysaccharides in their metabolites serve as a biofilm matrix, providing attachment sites and a protective barrier for symbiotic bacteria such as Lactobacilli. This synergistic interaction between bacterial communities enhances the quorum sensing signals of probiotics, promotes horizontal gene transfer between bacteria, and accelerates the optimization of beneficial metabolic pathways. For example, some Bifidobacteria can transfer acid-resistance genes to Lactobacilli via conjugative plasmids, improving the gastric acid tolerance of the entire microbial community.
From a temporal perspective, the growth-promoting effect of prebiotics exhibits a phased pattern. In the initial phase (0-12 hours), prebiotics are rapidly absorbed as substrates, promoting the exponential growth of probiotics. In the mid-term (12-48 hours), metabolic products accumulate, forming an ecological barrier that inhibits competition from harmful bacteria. In the late phase (48-72 hours), the bacterial flora stabilizes, and probiotics establish long-term colonization through biofilm formation. This dynamic balance accelerates the recovery of the intestinal microbiome by over 50% compared to supplementing with probiotics alone.
Notably, the synergistic effect of prebiotics and probiotics is significantly influenced by the ratio of their ingredients. Beijianyichang Prebiotics and Probiotics utilize a golden ratio of fructooligosaccharides to galacto-oligosaccharides (2:1). This ratio is designed based on the different nutritional requirements of Bifidobacteria and Lactobacilli: Fructooligosaccharides favor Bifidobacteria growth, while galacto-oligosaccharides are more selective for Lactobacilli. This strategic ratio enables the synergistic growth of the two main probiotics to reach 1.8 times the efficiency of single-bacterium supplementation.
Prebiotics, through multiple mechanisms including precise nutrient supply, metabolic product synergy, and niche optimization, create a comprehensive support system for probiotic growth. In Beijianyichang's prebiotics and probiotics products, this systematic design not only improves the intestinal survival rate of probiotics but also achieves long-term stability and enhanced function of the intestinal microbiome through profound adjustments to the bacterial flora.
